There are a lot of set up options for Civ 5, but not enough.
The Civ 5 Advanced Setup mod adds even more options for setting up your Civ 5 game, including adding extra resources so that you can balance cities or indeed, entire civilizations around a single resource.
Other advanced options include:
Civ 5 Starting Unit Mod options.
With the really advanced set up mod, you can change the type of units you begin the game with.
You can add different types of units and set their experience levels before the game begins. It is possible to boost units for all players, or create a handicap by providing some players with more and better experienced units than others.
Civ 5 Increased visibility.
Not being able to see what’s going on when you start the game can lead to losing several turns to meaningless exploration.
Civilization 5 Deity Strategy Guides - Advanced Options and Starting Location
You can increase this visibility to ten tiles, making city location selection a breeze. It will also allow you to see resources located within ten tiles of your starting position, as well as other civilizations, and terrain features that might be relevant to the founding of your great empire.
Civ 5 Starting bonuses.
If you’re tired of starting with a settler and maybe a scout unit and no technology at all, then adding in starting bonuses including free technologies, gold, faith and more will help your civilization get off to a running start.
Civ 5 Civilization destroyer.
(Otherwise known as Active Civilization selector).
With this option, you’ll be able to decide which civilizations you want to play with and which ones you want to wipe from the face of the world before they’ve even had a chance to found a single city.
This mod can be found on the Civ Fanatics forum, and is still in the process of being updated, so it is worth keeping your eye out for new versions.
Civ 5 Advanced Setup Mod